中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (8): 1556-1557.doi: 10.4103/1673-5374.303029

• 观点:退行性病与再生 • 上一篇    下一篇

直接口服抗凝剂:一种针对阿尔茨海默病的新疗法?

  

  • 出版日期:2021-08-15 发布日期:2021-01-13

Direct oral anticoagulants: a new therapy against Alzheimer’s disease?

Klaus Grossmann*   

  1. Center for Plant Molecular Biology (ZMBP), University of Tübingen, Tübingen, Germany
  • Online:2021-08-15 Published:2021-01-13
  • Contact: Klaus Grossmann, PhD, klaus.grossmann@uni-tuebingen.de.

摘要: https://orcid.org/0000-0001-5644-0003
(Klaus Grossmann) 

Abstract: More than 40 million people worldwide are thought to be affected by Alzheimer´s disease (AD). Of these, estimated less than 10% develop symptoms usually well before the age of 65, due to familial (hereditary) AD predisposition (Sierksma et al., 2020). AD is a multifactorial disorder, which includes a multitude of progressive degenerations in the brain parenchyma, but also in the vascular and hemostatic system. Currently, no drug is available or recognizable in the research pipeline for the effective treatment of this terrible disease. Therefore, the search for novel more effective drugs is an urgent task of pharmaceutical research. Already in the 1970s, clinical studies with small groups of senile dementia patients showed a positive effect of anticoagulant treatment on disease development (Grossmann, 2020). Particularly, results of basic research in the last 6 years on a contribution of cerebrovascular dysfunction to AD have brought back to light this idea. This perspective paper summarizes the role of toxic proteins of amyloid-beta (Aβ), thrombin and fibrin as key drivers in triggering vascular dysfunction and derived neurodegenerative changes, which leads to AD, and discuss how they can be treated with direct oral anticoagulants (DOACs).