中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (9): 1774-1775.doi: 10.4103/1673-5374.306073

• 观点:退行性病与再生 • 上一篇    下一篇

tau蛋白疾病中caspase-2介导特异性位点tau蛋白裂解的分子意义

  

  • 出版日期:2021-09-15 发布日期:2021-02-05

The molecular implications of a caspase-2-mediated site-specific tau cleavage in tauopathies

Peng Liu, Karen H. Ashe*   

  1. Department of Neurology, University of Minnesota, Minneapolis, MN, USA (Liu P, Ashe KH)
    Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA (Ashe KH)
    N. Bud Grossman Center for Memory Research and Care, University of Minnesota, Minneapolis, MN, USA (Liu P, Ashe KH)
    Geriatric Research, Education, and Clinical Centers, Veterans Affairs Medical Center, Minneapolis, MN, USA (Ashe KH)
  • Online:2021-09-15 Published:2021-02-05
  • Contact: Karen H. Ashe, MD, PhD, hsiao005@umn.edu.
  • Supported by:
    The work was supported by National Institutes of Health R01 AG060766 and R01 AG062199 (to KHA).

    The authors acknowledge Kathryn M. Nelson for insightful discussions. 

摘要: https://orcid.org/0000-0001-6724-9327
(Karen H. Ashe) 

Abstract: A major focus of current experimental therapies for neurodegenerative diseases is on modulating post-translational modifications (PTMs) of the microtubule-associated protein tau. Tau is a highly soluble, neuronal protein that is comprised of four domains – the N-terminal projection domain, the proline-rich region, the microtubule-binding domain, and the C-terminal tail. As a scaffold protein, tau dynamically interacts with numerous structural and functional biomolecules, such as cytoskeleton and motor proteins, chaperones, enzymes, DNA, RNA, and lipids. Over a dozen types of PTMs, combined with alternative splicing, confer upon tau its enormous structural heterogeneity, which subserves its many (patho-)physiological functions.