中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (9): 1770-1771.doi: 10.4103/1673-5374.306087

• 观点:退行性病与再生 • 上一篇    下一篇

人干细胞来源的小胶质细胞将成为阿尔茨海默病研究必不可少的工具箱

  

  • 出版日期:2021-09-15 发布日期:2021-02-05

Human stem cell-derived microglia will be an indispensable toolbox for Alzheimer’s disease research

Tongfei Liu*   

  1. Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong Province, China
  • Online:2021-09-15 Published:2021-02-05
  • Contact: Tongfei Liu, PhD, liutongfei1983@gmial.com.

摘要: https://orcid.org/0000-0002-3553-6871
(Tongfei Liu) 

Abstract: Alzheimer’s disease (AD) is the most common age-related dementia without cures. Between 2000 and 2017, deaths resulting from AD increased 145%. Based on the latest statistical data, more than 50 million people in the world suffered this devastating disease, which is one of major burdens in modern public health system (Alzheimer’s Association, 2020). Genetic mappings have uncovered numerous susceptibility genetic variants, the vast majority of which are located in noncoding regions of the genome.