中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2021, Vol. 16 ›› Issue (10): 1935-1943.doi: 10.4103/1673-5374.308068

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤后的蛋白质翻译后修饰

  

  • 出版日期:2021-10-15 发布日期:2021-03-18

Protein post-translational modifications after spinal cord injury

Shuang Zhu1, #, Bing-Sheng Yang1, #, Si-Jing Li1, Ge Tong2, Jian-Ye Tan1, Guo-Feng Wu1, Lin Li1, Guo-Li Chen3, *, Qian Chen4, *, Li-Jun Lin1, *    

  1. 1Department of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China; 2Department of Medical Ultrasonics, Guangdong Province Key Laboratory of Hepatology Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China; 3Department of Orthopedics, Affiliated Hospital of Putian University, Putian, Fujian Province, China; 4Cell and Molecular Biology Laboratory, Department of Orthopaedics, Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI, USA
  • Online:2021-10-15 Published:2021-03-18
  • Contact: Li-Jun Lin, MD, PhD, gost1@smu.edu.cn; Qian Chen, PhD, qian_chen@brown.edu; Guo-Li Chen, MD, PhD, ggllchen@163.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81801210 (to SZ).

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摘要：

Neural Regen Res：脊髓损伤后的翻译后修饰

脊髓损伤会导致一系列功能损害和心理并发症，给患者、家庭和社会带来灾难。据报道，全世界有2000多万人受到脊髓损伤的影响，他们的生活早已无法自理。因此，几个世纪以来，科学家和医生一直在努力寻找一种有效的治疗策略。脊髓损伤后的蛋白质翻译后修饰在近几十年引起了科学家们的兴趣。

来自南方医科大学珠江医院骨科中心的Shuang Zhu团队认为尽管蛋白质翻译后修饰靶向治疗在脊髓损伤中具有优势，但其存在一定局限性。首先，许多蛋白质翻译后修饰的靶点是不同的，这使得药物学上难以靶向这些蛋白质翻译后修饰。其次，创伤后不同时间点蛋白质翻译后修饰功能不同，难以确定靶向蛋白质翻译后修饰的适宜时间。最后，但并非最重要的是，脊髓损伤后神经元再生失败的原因有多种，一种特异性蛋白质翻译后修饰只调节其内在再生能力或抑制分子或胶质瘢痕，可能不足以保证有意义的恢复。对于大多数脊髓损伤患者来说，完全康复是不现实的，治疗策略应注重逐步功能恢复和生活质量改善。对于翻译后修饰治疗，神经痛控制的研究可能比运动或感觉恢复更为迫切。研究表明蛋白质翻译后修饰在神经病变疼痛缓解中起作用。此外，阻碍轴突再生的因素也各不相同，应研究针对多个因素的蛋白质翻译后修饰的组合。此外，细胞移植和基因治疗等其他治疗策略在蛋白质翻译后修饰调节的基础上可能会显著增加疗效。

这项成果撰写的文章发表在《中国神经再生研究（英文版）》杂志2021年10期。

https://orcid.org/0000-0002-4077-1198 (Li-Jun Lin); https://orcid.org/0000-0003-4406-5618 (Qian Chen); 
https://orcid.org/0000-0002-7778-2149 (Guo-Li Chen) 

Abstract: Deficits in intrinsic neuronal capacities in the spinal cord, a lack of growth support, and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating consequences. As such, one of the primary targets for the treatment of spinal cord injury is to develop strategies to antagonize extrinsic or intrinsic axonal growth-inhibitory factors or enhance the factors that support axonal growth. Among these factors, a series of individual protein level disorders have been identified during the generation of axons following spinal cord injury. Moreover, an increasing number of studies have indicated that post-translational modifications of these proteins have important implications for axonal growth. Some researchers have discovered a variety of post-translational modifications after spinal cord injury, such as tyrosination, acetylation, and phosphorylation. In this review, we reviewed the post-translational modifications for axonal growth, functional recovery, and neuropathic pain after spinal cord injury, a better understanding of which may elucidate the dynamic change of spinal cord injury-related molecules and facilitate the development of a new therapeutic strategy for spinal cord injury.

Key words: extracellular matrix, function impairment, glial scar, nerve regeneration, neuropathic pain, post-translational modification, spinal cord injury, therapeutic target