中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (5): 963-971.doi: 10.4103/1673-5374.324823

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

基于生物流体的生物标志物在脊髓损伤诊断治疗中的应用价值

  

  • 出版日期:2022-05-15 发布日期:2021-11-08

Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury

Hong-Da Wang1, 2, #, Zhi-Jian Wei1, 2, 3, 4, #, Jun-Jin Li1, 2, Shi-Qing Feng1, 2, 3, 4, *   

  1. 1Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China; 2International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin Medical University General Hospital, Tianjin, China; 3Department of Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China; 4Shandong University Center for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China
  • Online:2022-05-15 Published:2021-11-08
  • Contact: Shi-Qing Feng, sqfeng@tmu.edu.cn.
  • Supported by:
    This work was financially supported by the National Key Research and Development Project of Stem Cell and Transformational Research, No. 2019YFA0112100 (to SQF).

摘要: Neural Regen Res: 基于生物流体的脊髓损伤生物标志物
目前在脊髓损伤患者中进行的新研究已经证实,生物流体(Bio-fluid)中的一些生物标志物在脊髓损伤诊断中具有很大的应用潜力,已成为了目前脊髓损伤诊断领域关注的热点。
中国天津医科大学总医院王鸿达等在其一项最新综述中,阐述了目前最新发现的脊髓损伤相关生物标志物的研究进展及应用前景:(1)大多数结构蛋白如胶质纤维酸性蛋白、S100-β、泛素羧基末端水解酶L1、神经丝蛋白L和tau蛋白,均与急性脊髓损伤的诊断、脊髓损伤分级(AIS)和预后有不同程度的相关性;(2)炎症性细胞因子包括白细胞介素6、白细胞介素8和肿瘤坏死因子α,在脊髓损伤的急性和慢性阶段作为其诊断生物标记中都表现出了良好效应;(3)非编码RNA如miRNA和lncRNA对脊髓损伤的诊断也具有一定的潜力;(4)微量元素(镁、硒、铜、锌)可能与脊髓损伤后的运动恢复有关,可预测脊髓损伤后的运动功能;(5)体液标志物可反映脊髓损伤的病理生理变化:它的优点是便宜、采样方便和易于动态追踪,而其缺点是其影响因素众多以及这些标志物表达水平不稳定;(6)尽管上述各种相关指标已被证实是脊髓损伤的潜在生物标记并各具特色,但仍需要从大型临床和前瞻性研究中获得更令人信服的证据来识别在脊髓损伤的诊断和预后中最有价值的生物标志物。 
文章研究成果发表在《中国神经再生研究(英文版)》杂志2022年5月第5期。

Abstract: Recent studies in patients with spinal cord injuries (SCIs) have confirmed the diagnostic potential of biofluid-based biomarkers, as a topic of increasing interest in relation to SCI diagnosis and treatment. This paper reviews the research progress and application prospects of recently identified SCI-related biomarkers. Many structural proteins, such as glial fibrillary acidic protein, S100-β, ubiquitin carboxy-terminal hydrolase-L1, neurofilament light, and tau protein were correlated with the diagnosis, American Spinal Injury Association Impairment Scale, and prognosis of SCI to different degrees. Inflammatory factors, including interleukin-6, interleukin-8, and tumor necrosis factor α, are also good biomarkers for the diagnosis of acute and chronic SCI, while non-coding RNAs (microRNAs and long non-coding RNAs) also show diagnostic potential for SCI. Trace elements (Mg, Se, Cu, Zn) have been shown to be related to motor recovery and can predict motor function after SCI, while humoral markers can reflect the pathophysiological changes after SCI. These factors have the advantages of low cost, convenient sampling, and ease of dynamic tracking, but are also associated with disadvantages, including diverse influencing factors and complex level changes. Although various proteins have been verified as potential biomarkers for SCI, more convincing evidence from large clinical and prospective studies is thus required to identify the most valuable diagnostic and prognostic biomarkers for SCI.

Key words: biomarker, diagnosis, inflammatory cytokine, motor recovery, non-coding RNA, prognosis, spinal cord injury, structural protein, trace element