中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (5): 972-977.doi: 10.4103/1673-5374.324824

• 综述:退行性病与再生 • 上一篇    下一篇

石斛碱对阿尔茨海默病的神经保护

  

  • 出版日期:2022-05-15 发布日期:2021-11-08

Potential neuroprotection by Dendrobium nobile Lindl alkaloid in Alzheimer’s disease models

Dai-Di Li1, 2, Chang-Qing Zheng1, Feng Zhang1, *, Jing-Shan Shi1, *   

  1. 1Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou Province, China; 2School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • Online:2022-05-15 Published:2021-11-08
  • Contact: Jing-Shan Shi, MD, PhD, sjs@zmu.edu.cn; Feng Zhang, MD, PhD, zhangfengzmc@163.com.
  • Supported by:
    This work was supported by Shijingshan’s Tutor Studio of Pharmacology, No. GZS-2016-07 (to JSS); the Construction of National First Class Pharmacy Disciplineb, No. GESR-2017-85 (to JSS); the Master Start Foundation of Zunyi Medical University, No. F-839 (to DDL) and a grant from Guizhou Chinese Medicine Administration, No. QZYY-2018-025 (to DDL).

摘要: Neural Regen Res: 石斛碱阿尔茨海默病的神经保护作用
阿尔茨海默病是一种常见的神经退行性疾病,近年来患病率的急剧增加。目前的阿尔茨海默病临床治疗方法只能暂时缓解症状,但不能阻止认知能力的下降,因此迫切需要寻求安全有效的疗法。金钗石斛碱是金钗石斛的主要活性成分,传统中医证明金钗石斛碱能抗衰老,延长寿命和调节免疫功能。
遵义医科大学李戴弟所在课题组进行的一项综述主要总结了金钗石斛碱对阿尔茨海默病神经保护的多种潜在作用机制,以期为金钗石斛碱治疗阿尔茨海默病提供依据。研究结果显示,目前金钗石斛碱的神经保护作用仍局限在动物疾病模型研究中,临床研究尚未有效开展。金钗石斛碱能改善阿尔茨海默病动物模型的认知功能障碍,其神经保护机制可能与减少细胞外淀粉样斑块的产生,调节Tau蛋白的过度磷酸化,抑制神经炎症和神经元凋亡,激活自噬以及促进神经元再生密切相关。

文章发表在《中国神经再生研究(英文版)》杂志2022年5月第5期。

https://orcid.org/0000-0002-0968-7094 (Jing-Shan Shi); https://orcid.org/0000-0003-1122-3640 (Feng Zhang)

Abstract: At present, treatments for Alzheimer’s disease can temporarily relieve symptoms but cannot prevent the decline of cognitive ability and other neurodegenerative changes. Dendrobium nobile Lindl alkaloid is the main active component of Dendrobium nobile Lindl. Dendrobium nobile Lindl alkaloid has been shown to resist aging, prolong life span, and exhibit immunomodulatory effects in animals. This review summarizes the mechanisms behind the neuroprotective effects reported in Alzheimer’s disease animal models. The neuroprotective effects of Dendrobium nobile Lindl alkaloid have not been studied in patients. The mechanisms by which Dendrobium nobile Lindl alkaloid has been reported to improve cognitive dysfunction in Alzheimer’s disease animal models may be associated with extracellular amyloid plaque production, regulation of tau protein hyperphosphorylation, inhibition of neuroinflammation and neuronal apoptosis, activation of autophagy, and enhanced synaptic connections. 

Key words: Alzheimer’s disease, amyloid β plaques, animal models, Dendrobium nobile Lindl alkaloid, neural regeneration, neurofibrillary tangle, neuroinflammation, neuroprotection, pharmacokinetics, Tau protein