中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (9): 1893-1897.doi: 10.4103/1673-5374.329003

• 综述:周围神经损伤修复保护与再生 • 上一篇    下一篇

周围神经系统细胞外基质环境中的神经元-纤维支架界面：整合和结构要求

  

  • 出版日期:2022-09-15 发布日期:2022-03-05

Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements

Sanaz Behtaj1, 2, *, James A. St John1, 2, 3, Jenny A. K. Ekberg1, 2, 3, Maksym Rybachuk4, 5   

  1. 1Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Queensland, Australia; 2Menzies Health Institute Queensland, Griffith University, Southport, Australia; 3Griffith Institute for Drug Discovery, Nathan, Australia; 4School of Engineering and Built Environment, Griffith University, Nathan, Australia; 5Centre for Quantum Dynamics and Australian Attosecond Science Facility, Griffith University, Nathan, Australia
  • Online:2022-09-15 Published:2022-03-05
  • Contact: Sanaz Behtaj, PhD, sanaz.behtaj@griffithuni.edu.au.
  • Supported by:
    This work was supported by a Garnett-Passe and Rodney Williams Memorial Foundation grant (to JE) and a National Health and Medical Research Council grant, No. APP1183799 (to JASJ and JAKE).

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摘要： Neural Regen Res：3D神经元-纤维支架为周围神经系统修复提供可能
在严重神经损伤的情况下，周围神经系统的神经无法有效再生。神经组织工程的最新发现为应用纤维组织工程支架促进组织再生和功能恢复开辟了有新途径。
来自澳大利亚格里菲斯大学的Sanaz Behtaj团队认为，基于当前使用的治疗方式，周围神经长距离轴突修复仍然是一个挑战。创造支持性微环境可以弥合神经损伤区域并提高再生率。当前技术能够制造具有3D空间取向、纤维排列和结构的电纺支架，这在模仿周围神经的天然细胞外基质方面非常有前途。然而，在临床应用之前，需要进一步评估神经支架的功能结果以及其适用性。总之，将3D神经元-纤维支架有效地应用于临床治疗需要神经科学、基因工程、细胞移植、材料科学、材料工程和纳米技术等领域的协作。
文章在《中国神经再生研究（英文版）》杂志2022年9 月9 期发表。

Abstract: The nerves of the peripheral nervous system are not able to effectively regenerate in cases of severe neural injury. This can result in debilitating consequences, including morbidity and lifelong impairments affecting the quality of the patient’s life. Recent findings in neural tissue engineering have opened promising avenues to apply fibrous tissue-engineered scaffolds to promote tissue regeneration and functional recovery. These scaffolds, known as neural scaffolds, are able to improve neural regeneration by playing two major roles, namely, by being a carrier for transplanted peripheral nervous system cells or biological cues and by providing structural support to direct growing nerve fibers towards the target area. However, successful implementation of scaffold-based therapeutic approaches calls for an appropriate design of the neural scaffold structure that is capable of up- and down-regulation of neuron-scaffold interactions in the extracellular matrix environment. This review discusses the main challenges that need to be addressed to develop and apply fibrous tissue-engineered scaffolds in clinical practice. It describes some promising solutions that, so far, have shown to promote neural cell adhesion and growth and a potential to repair peripheral nervous system injuries.

Key words: electrospun scaffold, extracellular matrix, nerve conduit, neural tissue engineering, physical lumen filler, scaffold topography, structural support, surface interaction