中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (7): 1503-1504.doi: 10.4103/1673-5374.330604

• 观点:颅神经损伤修复保护与再生 • 上一篇    下一篇

α-突触核蛋白作为帕金森病的生物标志物:专注于神经源性细胞外囊泡

  

  • 出版日期:2022-07-15 发布日期:2022-01-17

Alpha-synuclein as a biomarker in Parkinson’s disease: focus on neural derived extracelluar vesicles

Cristina Agliardi*, Franca R. Guerini, Mario Meloni, Mario Clerici   

  1. IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy (Agliardi C, Guerini FR, Meloni M, Clerici M)
    Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy (Clerici M)
  • Online:2022-07-15 Published:2022-01-17
  • Contact: Cristina Agliardi, PhD, cagliardi@DONGNOCCHI.IT.

摘要: https://orcid.org/0000-0003-2022-3386 (Cristina Agliardi)

Abstract: The prevalence of Parkinson’s disease (PD) is rapidly increasing, and more than 12 million people are expected to suffer from PD by 2040. PD is a highly invalidating neurodegenerative condition that arises from the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. The main cause for such degeneration is the formation of cytoplasmic inclusions known as Lewy bodies, which include both misfolded α-synuclein (α-syn) protein and a multitude of fragmented membranes, organelles, and vesicles (Shahmoradian et al., 2019; Lashuel, 2020). No reliable biomarkers that can predict the onset of PD in its prodromal phase or could assess disease progression are currently available. α-Syn plays a pivotal role in the pathogenesis of PD and is present in peripheral tissues and biofluids; this led to the investigation of α-syn as a possible PD biomarker.