中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (7): 1481-1483.doi: 10.4103/1673-5374.330605

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

中枢神经系统再生中的 CXCR4 信号:是敌是友?

  


  • 出版日期:2022-07-15 发布日期:2022-01-15

CXCR4 signaling in central nervous system regeneration: friend or foe?

Daniel Terheyden-Keighley, Alexander M. Hilla, Dietmar Fischer*   

  1. Department of Cell Physiology, Ruhr University of Bochum, Universitätsstraβe 150, 44780 Bochum, Germany
  • Online:2022-07-15 Published:2022-01-15
  • Contact: Dietmar Fischer, PhD, dietmar.fischer@rub.de.
  • Supported by:
    This work was funded by the Deutsche Forschungsgemeinschaft (to DF).

摘要: https://orcid.org/0000-0002-1816-3014 (Dietmar Fischer)

Abstract: The knockout of the chemokine C-X-C motif chemokine receptor 4 (CXCR4) in growth-stimulated retinal ganglion cells (RGCs) has a multiplicative effect on optic nerve regeneration. C-X-C motif chemokine ligand 12 (CXCL12), the exclusive ligand of CXCR4, is expressed and axonally transported by an RGC subpopulation, releasing the chemokine at the lesion site. CXCL12 attracts injured axons of a CXCR4-positive RGC subpopulation, mostly αRGC, thereby preventing extension into the distal nerve. Knockout of either CXCR4 or CXCL12 in RGCs overcomes the axonal entrapment at the lesion site and enables long-distance regeneration. Thus, CXCL12/CXCR4-dependent attraction of axons contributes to the failure of optic nerve regeneration. Here we briefly cover CXCR4-based neural motility, current mechanistic background, and future perspectives in central nervous system (CNS) regeneration.