中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (7): 1484-1485.doi: 10.4103/1673-5374.330606

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

预防性运动对脑出血的治疗潜力

  

  • 出版日期:2022-07-15 发布日期:2022-01-15

Therapeutic potential of prophylactic exercise for intracerebral hemorrhage

Keita Kinoshita, Kelly K. Chung, Hiroshi Katsuki, Ken Arai*   

  1. Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA (Kinoshita K, Chung KK, Arai K)
    Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan (Kinoshita K, Katsuki H)
  • Online:2022-07-15 Published:2022-01-15
  • Contact: Ken Arai, PhD, karai@partners.org.
  • Supported by:
    This work was supported in part by NIH.

摘要: https://orcid.org/0000-0003-1615-3258 (Ken Arai) 

Abstract: Physical activity helps promote and maintain our brain health, including memory and cognitive performance. Research has shown that exercise is a safe behavioral intervention that reduces the risk of hypokinetic diseases, such as hypertension, diabetes, and lipid metabolic disorders. In addition, accumulating evidence now suggests that increased physical activity has positive effects in both preventing and ameliorating multiple brain diseases, including stroke. Although stroke is often accompanied by severe long-term disability and dementia, exercise is considered effective in enhancing neurological functions, even in stroke patients. Recent systematic reviews and meta-analyses indicate that aerobic physical activity promotes multiple health outcomes, including neurological behaviors and cognitive performance in stroke patients (Luo et al., 2020). Pre-clinical studies using rodent models of stroke have also demonstrated that exercise has therapeutic potential by influencing neuroinflammation, neuroprotection, remyelination, and astrogliosis (Svensson et al., 2015). Because aging is a major risk factor for stroke, and because polypharmacy among older adult patients has become a serious social issue around the world, it is worthwhile pursuing the potential of exercise as a non-pharmacological therapy for stroke.