中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (7): 1486-1488.doi: 10.4103/1673-5374.330608

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

溶酶体在突触核蛋白病中的作用:关注胶质细胞

  

  • 出版日期:2022-07-15 发布日期:2022-01-17

The role of lysosomes in alpha-synucleinopathies: a focus on glial cells

Denise Balta, Friederike Zunke*   

  1. Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
  • Online:2022-07-15 Published:2022-01-17
  • Contact: Friederike Zunke, PhD, friederike.zunke@fau.de.
  • Supported by:
    This work was supported by the Interdisciplinary Center for Clinical Research (IZKF) at the University Hospital of the University of Erlangen-Nuremberg (Jochen-Kalden funding programme N8).

摘要: https://orcid.org/0000-0002-0408-6388 (Friederike Zunke)

Abstract: Lysosomes are the major degradative compartments within eukaryotic cells. Besides their role in the degradation and recycling of intra- and extracellular molecules, they further mediate important biological processes, such as immune signaling and perpetuation of nutrient- and energy homeostasis. Impairment of lysosomal function triggers the accumulation of catabolic products within the organelle resulting in lysosomal storage disorders (LSDs). Interestingly, clinical, molecular, and genetic studies further indicate a strong link between lysosomal dysfunction and neurodegenerative disorders, including Parkinson’s disease (PD). Because of the association of lysosomal dysfunction and protein aggregation of α-synuclein (α-Syn) in PD or multiple system atrophy (MSA), the role of lysosomal pathways has been a matter of recent studies, mostly focusing on neuronal cells. Although it is known that glial cells play an important role in disease pathology of PD and MSA, only few studies on the lysosomal pathways, within glial cells have been carried out. Hence, a better understanding of lysosomal function in glia is needed to elucidate disease pathogenesis and to search for novel therapeutic approaches.