中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (8): 1640-1644.doi: 10.4103/1673-5374.332126

• 综述:退行性病与再生 • 上一篇    下一篇

卡路里限制或饮食限制:它们可以在多大程度上保护大脑免受神经退行性疾病的侵害?

  

  • 出版日期:2022-08-15 发布日期:2022-01-21

Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?

Tayana Silva de Carvalho*   

  1. Herz-und Diabeteszentrum NRW (HDZ NRW), Bad Oeynhausen, Germany
  • Online:2022-08-15 Published:2022-01-21
  • Contact: Tayana Silva de Carvalho, PhD, carvalhotay89@gmail.com.
  • Supported by:
    This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq)/German Academic Exchange Service (DAAD) (290076/2014-5; to TSC).

摘要: https://orcid.org/0000-0003-0653-927X (Tayana Silva de Carvalho)

Abstract: Finding the correct nutritional intervention is one of the biggest challenges in treating patients with neurodegenerative diseases. In general, these patients develop strong metabolic alterations, resulting in lower treatment efficacy and higher mortality rates. However, there are still many open questions regarding the effectiveness of dietary interventions in neurodiseases. Some studies have shown that a reduction in calorie intake activates key pathways that might be important for preventing or slowing down the progression of such diseases. However, it is still unclear whether these neuroprotective effects are associated with an overall reduction in calories (hypocaloric diet) or a specific nutrient restriction (diet restriction). Therefore, here we discuss how commonly or differently hypocaloric and restricted diets modulate signaling pathways and how these changes can protect the brain against neurodegenerative diseases.

Key words: Alzheimer’s disease, diet therapy, dietary intervention, epilepsy, fasting, glucose restriction, hypocaloric diet, multiple sclerosis, Parkinson’s disease, stroke