中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (10): 2126-2130.doi: 10.4103/1673-5374.332133

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

强迫症患者的 WNT/β-catenin 通路和昼夜节律

  

  • 出版日期:2022-10-15 发布日期:2022-03-15

WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder

Alexandre Vallée1, Yves Lecarpentier2, Jean-Noël Vallée3, 4   

  1. 1Department of Clinical Research and Innovation (DRCI), Foch Hospital, Suresnes, France; 2Centre de Recherche Clinique, Grand Hôpital de l’Est Francilien (GHEF), Meaux, France; 3Laboratoire de Mathématiques et Applications (LMA), Université de Poitiers, Poitiers, France; 4Centre Hospitalier Universitaire (CHU) Amiens Picardie, Université Picardie Jules Verne (UPJV), Amiens, France
  • Online:2022-10-15 Published:2022-03-15
  • Contact: Alexandre Vallée, MD, PhD, alexandre.g.vallee@gmail.com.

摘要: https://orcid.org/0000-0001-9158-4467 (Alexandre Vallée) 

Abstract: The neuropsychiatric disease named obsessive-compulsive disorder is composed by obsessions and/or compulsions. Obsessive-compulsive disorder etiologies are undefined. However, numerous mechanisms in several localizations are implicated. Some studies showed that both glutamate, inflammatory factors and oxidative stress could have main functions in obsessive-compulsive disorder. Glycogen synthase kinase-3β, the major negative controller of the WNT/β-catenin pathway is upregulated in obsessive-compulsive disorder. In obsessive-compulsive disorder, some studies presented the actions of the different circadian clock genes. WNT/β-catenin pathway and circadian clock genes appear to be intricate. Thus, this review focuses on the interaction between circadian clock genes and the WNT/β-catenin pathway in obsessive-compulsive disorder.

Key words: circadian rhythms, glutamatergic pathway, inflammation, obsessive-compulsive disorder, oxidative stress, WNT/β-catenin pathway