中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (8): 1753-1754.doi: 10.4103/1673-5374.332136

• 观点:退行性病与再生 • 上一篇    下一篇

非侵入性磁共振方法评估阿尔茨海默病上视交叉核

  

  • 出版日期:2022-08-15 发布日期:2022-01-22

Evaluation of suprachiasmatic nucleus in Alzheimer’s disease with non-invasive magnetic resonance methods

Rico Singer, A. Alia*   

  1. Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands (Singer R, Alia A)
    Institute of Medical Physics and Biophysics, University of Leipzig, Leipzig, Germany (Alia A)
  • Online:2022-08-15 Published:2022-01-22
  • Contact: A. Alia, PhD,alia.aliamatysik@medizin.uni-leipzig.de

摘要: https://orcid.org/0000-0002-4900-9749 (A. Alia)

Abstract: AD is the most frequently diagnosed form of dementia, with the total number of AD patients worldwide expected to triple by 2050 compared to 2015 (Prince et al., 2015). Despite years of research, much of the AD pathology remains unclear with no treatment or cure available. Besides its two hallmarks, amyloid-β (Aβ) plagues and hyperphosphorylated tau tangles, a distortion of circadian rhythms is commonly observed. Furthermore, poor sleep quality or trouble falling asleep are common AD symptoms, sometimes developing 10–15 years before cognitive symptoms associated with AD (Ju et al., 2014).