中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (8): 1757-1758.doi: 10.4103/1673-5374.332146

• 观点:退行性病与再生 • 上一篇    下一篇

身心疗法如何减少阿尔茨海默病的病理特征

  

  • 出版日期:2022-08-15 发布日期:2022-01-22

How mind-body therapies might reduce pathological features of Alzheimer’s disease

Melanie Hüttenrauch, Susana Castro-Obregón*   

  1. División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM), Circuito Exterior SN, Ciudad Universitaria, CDMX, Mexico
  • Online:2022-08-15 Published:2022-01-22
  • Contact: Susana Castro-Obregón, PhD, scastro@ifc.unam.mx.

摘要: https://orcid.org/0000-0003-0549-5690 (Susana Castro-Obregón)

Abstract: Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder that is responsible for around 60–80% of all dementia cases and currently affects around 50 million people worldwide. As the population’s life span tends to increase, current predictions suggest that by 2050, 152 million people worldwide will suffer from dementia (Balsinha, 2019). While the exact cause of AD remains obscure, various hypotheses regarding AD etiology have been described in the last decades. According to the amyloid hypothesis, the pathogenic changes related to AD start with the accumulation of amyloid-beta (Aβ) in the brain. These Aβ peptides form oligomers and insoluble amyloid plaques which are neurotoxic and trigger harmful downstream events such as the aggregation of the microtubule-associated protein Tau into neurofibrillary tangles, chronic inflammation, and brain atrophy.