中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (9): 1929-1936.doi: 10.4103/1673-5374.335141

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

光照对健康人警觉的影响：系统综述与meta分析

  

  • 出版日期:2022-09-15 发布日期:2022-03-05

Alerting effects of light in healthy individuals: a systematic review and meta-analysis#br#

Yi-Man Mu1, 2, Xiao-Dan Huang3, Sui Zhu1, 2, Zheng-Fang Hu3, Kwok-Fai So3, 4, 5, 6, 7, Chao-Ran Ren3, 4, 5, 6, 7, Qian Tao1, 2, 5, 6, *   

  1. 1Department of Public Health and Preventive Medicine, School of Basic Medicine, Jinan University, Guangzhou, Guangdong Province, China; 2Division of Medical Psychology and Behavior Science, School of Basic Medicine, Jinan University, Guangzhou, Guangdong Province, China; 3Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong Province, China; 
    4Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, Guangdong Province, China; 5Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, Guangdong Province, China; 6Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Science, Qingdao, Shandong Province, China; 7Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China
  • Online:2022-09-15 Published:2022-03-05
  • Contact: Qian Tao, MD, taoqian16@jnu.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 82172530 (to QT); Science and Technology Program of Guangdong, No. 2018B030334001 (to CRR); Guangzhou Science and Technology Project, No. 202007030012 (to QT).

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摘要：

光在心理生物学或心理生理学过程中起着至关重要的作用，如警觉性。警觉效果受光的特点和干预时间的影响。文章首次系统地回顾了光干预对警觉性的影响，并讨论了光干预的最佳方案。通过系统性检索Web of Science，PubMed和PsycINFO数据库2021年8月以英文形式发表的研究的这项荟萃分析在PROSPERO注册完成了注册（CRD42020181485）。结局包括主观和客观的警觉性。亚组分析考虑了各种因素，如波长、相关色温（CCT）、光的照度和时间特征。这项荟萃分析包括27项交叉研究和2项平行组研究，共纳入1210名健康参与者（636名（52%）男性，平均年龄25.62岁）。结果发现，光干预对健康受试者的主观警觉性（SMD=-0.28，95%CI=-0.49 to -0.06，P=0.01）和客观警觉性（SMD=-0.34，95%CI=-0.68 to -0.01，P=0.04）都有积极影响。亚组结果显示，冷光在改善主观警觉性（SMD = -0.37，95% CI = -0.65 to -0.10，P = 0.007，I2 = 26%）和客观警觉性（SMD = -0.36，95% CI = -0.66 to -0.07，P = 0.02，I2= 0）方面比暖光更好。白天（SMD = -0.22, 95% CI = -0.37 to -0.07, P = 0.005, I2 = 74%）和夜间（SMD = -0.32, 95% CI = -0.61 to -0.02, P = 0.04, I2 = 0）光照都改善了主观警觉性。这项分析结果表明：（1）光照与主观和客观警觉性的明显改善有关；（2）较高相关色温的光照在改善警觉性方面比较低相关色温的光照更有成效；（3）白天和夜间的光照都能改善主观警觉性。

https://orcid.org/0000-0002-9725-1871 (Qian Tao)

Abstract: Light plays an essential role in psychobiological and psychophysiological processes, such as alertness. The alerting effect is influenced by light characteristics and the timing of interventions. This meta-analysis is the first to systematically review the effect of light intervention on alertness and to discuss the optimal protocol for light intervention. In this meta-analysis, registered at PROSPERO (Registration ID: CRD42020181485), we conducted a systematic search of the Web of Science, PubMed, and PsycINFO databases for studies published in English prior to August 2021. The outcomes included both subjective and objective alertness. Subgroup analyses considered a variety of factors, such as wavelength, correlated color temperature (CCT), light illuminance, and timing of interventions (daytime, night-time, or all day). Twenty-seven crossover studies and two parallel-group studies were included in this meta-analysis, with a total of 1210 healthy participants (636 (52%) male, mean age 25.62 years). The results revealed that light intervention had a positive effect on both subjective alertness (standardized mean difference (SMD) = –0.28, 95% confidence interval (CI): –0.49 to  –0.06, P = 0.01) and objective alertness in healthy subjects (SMD = –0.34, 95% CI: –0.68 to –0.01, P = 0.04). The subgroup analysis revealed that cold light was better than warm light in improving subjective alertness (SMD = –0.37, 95% CI: –0.65 to –0.10, P = 0.007, I2 = 26%) and objective alertness (SMD = –0.36, 95% CI: –0.66 to  –0.07, P = 0.02, I2 = 0). Both daytime (SMD = –0.22, 95% CI: –0.37 to  –0.07, P = 0.005, I2 = 74%) and night-time (SMD = –0.32, 95% CI: –0.61 to –0.02, P = 0.04, I2 = 0) light exposure improved subjective alertness. The results of this meta-analysis and systematic review indicate that light exposure is associated with significant improvement in subjective and objective alertness. In addition, light exposure with a higher CCT was more effective in improving alertness than light exposure with a lower CCT. Our results also suggest that both daytime and night-time light exposure can improve subjective alertness.

Key words: correlated color temperature, illuminance, light, meta-analysis, objective alertness, subjective alertness, time of light intervention, wavelength