中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (10): 2200-2202.doi: 10.4103/1673-5374.335797

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

人血小板裂解物和层粘连蛋白的协同作用增强人脂肪干细胞的神经营养作用

  


  • 出版日期:2022-10-15 发布日期:2022-03-16

Synergy of human platelet lysate and laminin to enhance the neurotrophic effect of human adipose-derived stem cells

Pietro G di Summa*, Srinivas Madduri   

  1. Department of Plastic, Reconstructive and Hand Surgery, University Hospital of Lausanne, University of Lausanne, Lausanne, Switzerland (di Summa PG)
    Department of Surgery, Bioengineering and Neuroregeneration, University of Geneva, University Hospital Geneva, Geneva, Switzerland (Madduri S) 
  • Online:2022-10-15 Published:2022-03-16
  • Contact: Pietro G. di Summa, MD, PhD, pietro.di-summa@chuv.ch.
  • Supported by:
    The present work was supported by the Leenards Foundation for the economic support granted (to PGDS).

摘要: https://orcid.org/0000-0002-1431-4479 (Pietro G. di Summa)

Abstract: Despite the spontaneous regenerative capacity of the peripheral nervous system, clinical nerve repair often results in poor functional recovery with the high socio-economic burden. In presence of peripheral nerve injuries and when distal nerve transfers are not possible, nerve autografts, are the solution of choice to cross a critical nerve gap. However, these are associated with donor site morbidity and offer only suboptimal functional recovery. Thus, the need to improve the rate of effective regeneration has directed research attention towards stem cell therapy and nerve tissue engineering.