中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (11): 2439-2440.doi: 10.4103/1673-5374.335805

• 观点:脊髓损伤修复保护与再生 • 上一篇    下一篇

转录因子促进脊髓损伤后神经再生

  

  • 出版日期:2022-11-15 发布日期:2022-04-22

Transcription factors promote neural regeneration after spinal cord injury

Zachary Finkel, Li Cai*   

  1. Department of Biomedical Engineering, Rutgers University, Piscataway, NJ, USA
  • Online:2022-11-15 Published:2022-04-22
  • Contact: Li Cai, PhD, lcai@rutgers.edu.
  • Supported by:
    This work was supported by the State of New Jersey Commission on Spinal Cord Research grant 15IRG006 and Rutgers TechAdvance Fund (to LC).

摘要: https://orcid.org/0000-0003-3344-337X (Li Cai)

Abstract: Human spinal cord injury (SCI) results in locomotor and sensory disabilities, which severely affect the quality of life. To restore function after SCI, it is necessary to repair and reconstruct the damaged local circuitry. Major hurdles in neural regeneration include a limited level of neurogenesis in the adult spinal cord and an inflammatory microenvironment that inhibits neurogenesis and axon regeneration. In addition, neurons lost to injury are never replaced. Neural stem/progenitor cells (NSPCs) persist in the adult spinal cord and represent a potential cell source for tissue repair/regeneration after injury, and they are heterogeneous populations with a limited capacity to replenish the lost neuronal population (Hachem et al., 2020; Llorens-Bobadilla et al., 2020). Traumatic injury activates NSPCs in the central nervous system (CNS). However, injury-induced NSPCs largely differentiate into glial cells, i.e., astrocytes and oligodendrocytes, which contribute to glial scar formation. Promoting endogenous NSPCs to differentiate into functional neurons by transcription factors for regeneration and restoration of local neural circuitry is an emerging approach to develop therapeutics for traumatic CNS injury and neurodegenerative disorders.