中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (10): 2117-2125.doi: 10.4103/1673-5374.335822

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

脊髓损伤轴突修复过程中石墨烯及其衍生物的优势

  

  • 出版日期:2022-10-15 发布日期:2022-03-15

Graphene and graphene-based materials in axonal repair of spinal cord injury

Shi-Xin Wang1, Yu-Bao Lu2, 3, Xue-Xi Wang1, 4, Yan Wang1, Yu-Jun Song1, Xiao Wang1, Munkhtuya Nyamgerelt1   

  1. 1School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu Province, China; 2The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu Province, China; 3Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 4Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, Gansu Province, China
  • Online:2022-10-15 Published:2022-03-15
  • Contact: Xue-Xi Wang, PhD, wangxuexi@lzu.edu.cn.
  • Supported by:
    This work was supported by the Lanzhou Talent Innovation and Entrepreneurship Project, No. 2020-RC-40 (to XXW and YBL) and Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital, Nos. CYXZ2020-03, CYXZ2021-01 (both to YBL).

摘要: https://orcid.org/0000-0003-3168-8816 (Xue-Xi Wang)

Abstract: Graphene and graphene-based materials have the ability to induce stem cells to differentiate into neurons, which is necessary to overcome the current problems faced in the clinical treatment of spinal cord injury. This review summarizes the advantages of graphene and graphene-based materials (in particular, composite materials) in axonal repair after spinal cord injury. These materials have good histocompatibility, and mechanical and adsorption properties that can be targeted to improve the environment of axonal regeneration. They also have good conductivity, which allows them to make full use of electrical nerve signal stimulation in spinal cord tissue to promote axonal regeneration. Furthermore, they can be used as carriers of seed cells, trophic factors, and drugs in nerve tissue engineering scaffolds to provide a basis for constructing a local microenvironment after spinal cord injury. However, to achieve clinical adoption of graphene and graphene-based materials for the repair of spinal cord injury, further research is needed to reduce their toxicity.

Key words: axonal regeneration, graphene, graphene oxide, nerve axon regeneration, reduced graphene oxide, spinal cord contusions, spinal cord injury, spinal cord trauma