中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (10): 2102-2107.doi: 10.4103/1673-5374.335825

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

血小板源性细胞外囊泡对创伤性脑损伤诱导凝血功能障碍和炎症反应中的作用

  

  • 出版日期:2022-10-15 发布日期:2022-03-15

Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation

Liang Liu, Quan-Jun Deng   

  1. Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China
  • Online:2022-10-15 Published:2022-03-15
  • Contact: Quan-Jun Deng, MD, dqj2177@163.com.
  • Supported by:
    This work is supported by Scientific Research Program of Tianjin Education Commission (Natural Science) of China, No. 2019ZD034 (to QJD).

摘要: https://orcid.org/0000-0002-8718-1857 (Quan-Jun Deng)

Abstract: Extracellular vesicles are composed of fragments of exfoliated plasma membrane, organelles or nuclei and are released after cell activation, apoptosis or destruction. Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain injury. Accumulated laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain injury. This review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury.

Key words: angiogenesis, clotting factors, coagulopathy, delivery, inflammation, platelet-derived extracellular vesicles, review, target, traumatic brain injury