中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (10): 2093-2101.doi: 10.4103/1673-5374.335826

• 综述:退行性病与再生 •    下一篇

多酚和干细胞:改善神经退行性疾病的二重奏疗法


  

  • 出版日期:2022-10-15 发布日期:2022-03-15

Polyphenols as potential enhancers of stem cell therapy against neurodegeneration

Diana Rodríguez-Vera1, Antonio Abad-García1, Nancy Vargas-Mendoza1, Rodolfo Pinto-Almazán2, Eunice D. Farfán-García1, José A. Morales-González1, Marvin A. Soriano-Ursúa1   

  1. 1Sección de Estudios de Posgrado e Investigación. Escuela Superior de Medicina, Instituto Politécnico Nacional, México City, México; 2Unidad de Investigación, Hospital Regional de Alta Especialidad Ixtapaluca, Carretera Federal México-Puebla km 34.5, State of México, México
  • Online:2022-10-15 Published:2022-03-15
  • Contact: José A. Morales-González, PhD, jmorales101@yahoo.com.mx; Marvin A. Soriano-Ursúa, MD, PhD, msoriano@ipn.mx.
  • Supported by:
    This work was supported by Secretaria de Investigación y Posgrado del Instituto Politécnico Nacional (IPN), No. M-2143.

摘要: https://orcid.org/0000-0002-6529-1502 (Marvin A. Soriano-Ursúa)

Abstract: The potential of polyphenols for treating chronic-degenerative diseases (particularly neurodegenerative diseases) is attractive. However, the selection of the best polyphenol for each treatment, the mechanisms by which they act, and their efficacy are frequently discussed. In this review, the basics and the advances in the field, as well as suggestions for using natural and synthetic polyphenols alone or in a combinatorial strategy with stem cell assays, are compiled and discussed. Thus, stem cells exhibit several responses when polyphenols are added to their environment, which could provide us with knowledge for advancing the elucidation of the origin of neurodegeneration. But also, polyphenols are being included in the innovative strategies of novel therapies for treating neurodegenerative diseases as well as metabolic diseases related to neurodegeneration. In this regard, flavonoid compounds are suggested as the best natural polyphenols due to their several mechanisms for acting in ameliorative effects; but increasing reports are involving other polyphenols. Even if some facts limiting bioactivity prevent them from conventional use, some natural polyphenols and derivatives hold the promise for being improved compounds, judged by their induced effects. The current results suggest polyphenols as enhancers of stem cell therapy against the targeted diseases.

Key words: Alzheimer’s disease, chronic degenerative diseases, combinatorial therapy, metabolism, neurodegenerative diseases, neuronal damage, neuroprotection, Parkinson’s disease, polyphenols, stem cell assays