中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (10): 2149-2152.doi: 10.4103/1673-5374.336134

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

探索白细胞介素 27 在中枢神经系统疾病中作为神经元存活调节剂的作用

  

  • 出版日期:2022-10-15 发布日期:2022-03-15

Exploring the role of interleukin-27 as a regulator of neuronal survival in central nervous system diseases

Andrea N. Nortey, Kimberly N. Garces, Abigail S. Hackam   

  1. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
  • Online:2022-10-15 Published:2022-03-15
  • Contact: Abigail S. Hackam, PhD, ahackam@med.miami.edu.
  • Supported by:
    Financial support for this work for ASH was from National Eye Institute R01 EY026546 and an NEI Center Core Grant EY014801.

摘要: https://orcid.org/0000-0002-9282-7763 (Abigail S. Hackam)

Abstract: Interleukin-27 is a pleiotropic cytokine that is involved in tissue responses to infection, cell stress, neuronal disease, and tumors. Recent studies in various tissues indicate that interleukin-27 has complex activating and inhibitory properties in innate and acquired immunity. The availability of recombinant interleukin-27 protein and mice with genetic deletions of interleukin-27, its receptors and signaling mediators have helped define the role of interleukin-27 in neurodegenerative diseases. Interleukin-27 has been well-characterized as an important regulator of T cell activation and differentiation that enhances or suppresses T cell responses in autoimmune conditions in the central nervous system. Evidence is also accumulating that interleukin-27 has neuroprotective activities in the retina and brain. Interleukin-27 is secreted from and binds to infiltrating microglia, macrophage, astrocytes, and even neurons and it promotes neuronal survival by regulating pro- and anti-inflammatory cytokines, neuroinflammatory pathways, oxidative stress, apoptosis, autophagy, and epigenetic modifications. However, interleukin-27 can have the opposite effect and induce inflammation and cell death in certain situations. In this review, we describe the current understanding of regulatory activities of interleukin-27 on cell survival and inflammation and discuss its mechanisms of action in the brain, spinal cord, and retina. We also review evidence for and against the therapeutic potential of interleukin-27 for dampening harmful neuroinflammatory responses in central nervous system diseases.

Key words: central nervous system, cytokine, inflammatory, interleukin-27, neuroprotection, retina