中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (12): 2593-2599.doi: 10.4103/1673-5374.339471

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

microRNAs在脊髓缺血再灌注损伤中的作用

  

  • 出版日期:2022-12-15 发布日期:2022-05-05

The roles of microRNAs in spinal cord ischemia-reperfusion injury

Feng-Shou Chen#, Xiang-Yi Tong#, Bo Fang, Dan Wang, Xiao-Qian Li, Zai-Li Zhang*   

  1. Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning Province, China
  • Online:2022-12-15 Published:2022-05-05
  • Contact: Zai-Li Zhang, MD, PhD, zhangzaili333@sina.com.

摘要:

脊髓缺血再灌注损伤(SCII)与多种病理生理改变有关。诱发脊髓缺血再灌注损伤的基本机制尚未完全确定。微小RNA(miRNAs)是一类非编码RNAs,它是介导多种神经系统疾病的新靶点,调节众多的生理功能,包括细胞凋亡、自噬、炎症和血脊髓屏障损伤。已知miRNAs表达谱在脊髓缺血再灌注损伤后发生改变。因此,了解miRNAs在脊髓缺血再灌注损伤中的重要作用有助于开发针对该损伤的潜在预防和治疗策略。此综述总结了miRNAs与脊髓缺血再灌注损伤之间的关系,以及miRNAs在脊髓缺血再灌注损伤治疗中的潜在治疗标靶。

https://orcid.org/0000-0001-7897-8680 (Zai-Li Zhang)

Abstract: Spinal cord ischemia/reperfusion injury is a devastating medical disorder with poor prognosis that is associated with several pathophysiological conditions. However, multiple stimuli can trigger SCII, so the underlying mechanism of this pathology has not yet been fully established. MicroRNAs (miRNAs) are a class of non-coding RNAs that mediate a variety of nervous system diseases and regulate numerous physiological functions, including apoptosis, autophagy, inflammation, and blood-spinal cord barrier damage. miRNA expression profiles are known to be altered after spinal cord ischemia/reperfusion injury. Therefore, gaining a better understanding of the significant roles that miRNAs play in spinal cord ischemia/reperfusion injury could help develop potential preventive and therapeutic strategies for spinal cord ischemia/reperfusion injury. This review summarizes the current state of our knowledge about the relationship between miRNAs and spinal cord ischemia/reperfusion injury, as well as potential miRNAs that could be targeted to treat spinal cord ischemia/reperfusion injury.

Key words: apoptosis, autophagy, blood-spinal cord barrier, inflammation, microRNAs, pathophysiology, review, spinal cord ischemia-reperfusion injury