中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 322-323.doi: 10.4103/1673-5374.343909

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

了解胎儿生长受限导致脑损伤的时机:来自仔猪自发生长受限模型的经验教训

  

  • 出版日期:2023-02-15 发布日期:2022-08-06

Understanding the timing of brain injury in fetal growth restriction: lessons from a model of spontaneous growth restriction in piglets

Hannah Musco, Julie A. Wixey*   

  1. UQ Centre for Clinical Research, Faculty of Medicine, University of Queensland, Queensland, Australia
  • Online:2023-02-15 Published:2022-08-06
  • Contact: Julie A. Wixey, PhD, j.wixey@uq.edu.au.
  • Supported by:
    JAW was supported by a University of Queensland Stimulus Fellowship.

摘要: https://orcid.org/0000-0002-9716-8170 (Julie A. Wixey)

Abstract: Fetal growth restriction (FGR) is one of the most common contributors to increased risk of mortality in the fetal/neonatal period and long-term morbidity in the infant (Malhotra et al., 2019). FGR can arise from many pathophysiological processes associated with maternal, fetal, genetic, or placental compromise; however, placental insufficiency is the most common cause of FGR. Placental insufficiency during pregnancy results in chronic fetal hypoxia where a lack of oxygen and nutrients supply to the developing fetus impacts normal development of the fetus. The fetal brain is especially vulnerable to FGR conditions. Neuronal and white matter injury are major pathophysiological features of FGR with clinical imaging studies identifying lower grey and white matter complexity in FGR preterm infants compared with both preterm and term infants (Esteban et al., 2010). These structural abnormalities remain at one year of age and are associated with neurodevelopmental disabilities (Esteban et al., 2010). Unfortunately, there are currently no interventions for the prevention or treatment of these structural brain alterations in the FGR infant. Determining mechanisms of brain injury and the timing of these injury processes (i.e., when they are initiated) would greatly assist with the identification and timing of treatment options for FGR to improve brain outcomes.