中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (2): 320-321.doi: 10.4103/1673-5374.343912

• 观点:退行性病与再生 • 上一篇    下一篇

海马 CA2 区的红藻氨酸受体

  

  • 出版日期:2023-02-15 发布日期:2022-08-06

Kainate receptors in the CA2 region of the hippocampus

Yuniesky Andrade-Talavera, Antonio Rodríguez-Moreno*   

  1. Laboratorio de Neurociencia Celulary Plasticidad, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain
  • Online:2023-02-15 Published:2022-08-06
  • Contact: Antonio Rodríguez-Moreno, PhD, arodmor@upo.es.
  • Supported by:
    The work performed in ARM laboratory received support from the Agencia Estatal de Investigación and FEDER (BFU2015-68655-P).

摘要: https://orcid.org/0000-0002-8078-6175 (Antonio Rodríguez-Moreno)

Abstract: The hippocampus is involved in important brain functions such as learning and memory, spatial navigation, fear processing, and social behavior (Dudek et al, 2016). The most prominent areas of the hippocampus are typically denoted as the dentate gyrus and the three areas of the cornu ammonis (CA1, CA2, and CA3). Discovered by Lorente de Nó (1934), the CA2 region of the hippocampus is a relatively small area interposed between CA3 and CA1 that forms the nexus linking the input of the entorhinal cortex to the output of CA1 (Chevaleyre and Siegelbaum, 2010). Although little is known about the function of CA2 in detail (Hitti and Siegelbaum, 2014; Dudek et al., 2016), there is currently increasing interest in its physiology and cumulative evidence indicates that this region has important and unique properties as it participates in engram formation, neurodegeneration and information processing (Hainmueller and Bartos, 2018; Pang et al., 2019; Middleton and Mchugh, 2020; Lehr et al., 2021). Recent discoveries have revealed that CA2 is involved in the formation of social and spatio/temporal memories (Hitti and Siegelbaum, 2014; Dudek et al., 2016). In addition, the CA2 network seems to play a critical role in balancing levels of excitation and inhibition in the hippocampus (Boehringer et al., 2017). Importantly, excitation/inhibition imbalances have been implicated in the diverse brain and neurodevelopmental disorders.