中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (3): 525-526.doi: 10.4103/1673-5374.346473

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

用于脑疾病的纳米囊泡的生物制造

  

  • 出版日期:2023-03-15 发布日期:2022-08-26

Biofabrication of nanovesicles for brain diseases

Pasquale Picone*, Domenico Nuzzo*   

  1. Istituto per la Ricerca e l’Innovazione Biomedica, CNR; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università di Palermo, Palermo, Italy
  • Online:2023-03-15 Published:2022-08-26
  • Contact: Nuzzo, PhD, domenico.nuzzo@irib.cnr.it; Pasquale Picone, PhD, pasquale.picone@irib.cnr.it.

摘要: https://orcid.org/0000-0002-4325-417X (Domenico Nuzzo)
https://orcid.org/0000-0001-7127-2183 (Pasquale Picone)

Abstract: Nanotechnologies promise to improve disease diagnosis and treatment, overcoming the limitations of conventional administrations. In particular, extracellular vesicles (EVs) and artificial vesicles (AVs) are strongly emerging tools in nanomedicine (Leggio et al., 2020). EVs are cell-derived membrane structures secreted after the fusion of endosomes with the plasma membrane (exosomes) or shed from the plasma membrane (microvesicles). EVs are released by different brain cells (neurons, oligodendrocytes, astrocytes, and microglia) and constitute a physiological intercellular communication system. Indeed, EVs can deliver different types of molecules (nucleic acids and proteins), which often influence the phenotype of the recipient cells. They play a physiological role in the central nervous system (CNS), such as development, myelination, regeneration, and synaptic activity (Lai et al., 2012). Due to their content, EVs could therefore constitute an important biomarker for neurodegenerative diseases, represent candidates for therapeutic use, enclosing regulatory molecules, or be considered as vectors for brain drug delivery (Croese et al., 2018).