中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (3): 503-505.doi: 10.4103/1673-5374.350189

• 综述:脑损伤修复保护与再生 • 上一篇    下一篇

褪黑素:一种多任务吲哚胺调节海马神经发生

  

  • 出版日期:2023-03-15 发布日期:2022-08-25

Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis

Alejandro Romero1, José Ángel Morales-García2, 3, 4, Eva Ramos1, *    

  1. 1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid; 2Institute for Biomedical Research “A. Sols” (CSIC-UAM); 3Spanish Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED); 4Department of Cellular Biology, School of Medicine, Complutense University of Madrid, Madrid, Spain 
  • Online:2023-03-15 Published:2022-08-25
  • Contact: Eva Ramos, PhD, eva.ramos@ucm.es.

摘要: https://orcid.org/0000-0001-5791-0687 (Eva Ramos)

Abstract: Neurodegeneration affects a large number of cell types including neurons, astrocytes or oligodendrocytes, and neural stem cells. Neural stem cells can generate new neuronal populations through proliferation, migration, and differentiation. This neurogenic potential may be a relevant factor to fight neurodegeneration and aging. In the last years, we can find growing evidence suggesting that melatonin may be a potential modulator of adult hippocampal neurogenesis. The lack of therapeutic strategies targeting neurogenesis led researchers to explore new molecules. Numerous preclinical studies with melatonin observed how melatonin can modulate and enhance molecular and signaling pathways involved in neurogenesis. We made a special focus on the connection between these modulation mechanisms and their implication in neurodegeneration, to summarize the current knowledge and highlight the therapeutic potential of melatonin. 

Key words: adult hippocampal neurogenesis, aging, melatonin, neural stem cell, neurodegeneration, neuroprotection, signaling pathway, therapeutic strategy