中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (5): 955-958.doi: 10.4103/1673-5374.355740

• 综述:退行性病与再生 • 上一篇    下一篇

患者特异性单核细胞衍生的小胶质细胞作为神经退行性疾病的筛查工具

  

  • 出版日期:2023-05-15 发布日期:2022-11-01

Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases

Hazel Quek1, 2, *, Anthony R. White1, 2   

  1. 1Mental Health and Neuroscience, QIMR Berghofer Medical Research Institute;  2School of Biomedical Science, The University of Queensland, Brisbane, QLD, Australia
  • Online:2023-05-15 Published:2022-11-01
  • Contact: Hazel Quek, PhD, hazel.quek@qimrberghofer.edu.au.
  • Supported by:
    This work was supported by grants from NHMRC (APP1125796), The Col Bambrick Memorial MND Research Grant, The NTI MND Research Grant, and the FightMND Foundation. ARW is supported by an NHMRC Senior Research Fellowship APP1118452.

摘要: https://orcid.org/0000-0001-5597-5372 (Quek Hazel)

Abstract: Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and in vivo rodent models lacked scalability, consistency, or physiological relevance, which deterred successful therapeutic outcomes for the past decade. Here we review human blood monocyte-derived microglia-like cells as a robust and consistent approach to generate a patient-specific microglia-like model that can be used in extensive cohort studies for drug testing. We will highlight the strength and applicability of human blood monocyte-derived microglia-like cells to increase translational outcomes by reviewing the advantages of human blood monocyte-derived microglia-like cells in addressing patient heterogeneity and stratification, the basis of personalized medicine.

Key words: human in vitro microglia models, neurodegeneration, neuroinflammation, patient heterogeneity, patient stratification, peripheral blood monocyte-derived microglia-like cells, therapeutic target, transdifferentiation, translational outcomes