中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (5): 959-968.doi: 10.4103/1673-5374.355751

• 综述:退行性病与再生 • 上一篇    下一篇

长链非编码RNA在衰老过程中的分子标志及其对衰老相关疾病的显著影响

  

  • 出版日期:2023-05-15 发布日期:2022-11-01

Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

Syed Aoun Mehmood Sherazi1, Asim Abbasi2, Abdullah Jamil3, Mohammad Uzair1, Ayesha Ikram4, Shanzay Qamar4, #br# Adediji Ayomide Olamide5, Muhammad Arshad1, Peter J. Fried6, Milos Ljubisavljevic7, Ran Wang8, 9, Shahid Bashir10 , *#br#   

  1. 1Department of Biological Sciences, Faculty of Basic & Applied Sciences, International Islamic University, Islamabad, Pakistan; 2Department of Biological Sciences, University of Arkansas, Fayetteville, AR, USA;  3Department of Pharmacology, Government College University, Faisalabad, Pakistan;  4Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan;  5Department of Chemistry, Chulalongkorn University, , Thailand;  6Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Beth Israel Deaconess Medical Center (KS 158), Harvard Medical School, Boston, MA, USA;  7Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates;  8Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China;  9Mental Health Institute of Hebei Medical University, Shijiazhuang, Hebei Province, China; 10Neuroscience Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia
  • Online:2023-05-15 Published:2022-11-01
  • Contact: Shahid Bashir, PhD, shahidbpk13@gmail.com.

摘要: https://orcid.org/0000-0001-6286-6895 (Shahid Bashir) 

Abstract: Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer’s disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes (e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA- and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging.

Key words: aging, Alzheimer’s disease, DNA sequence, epigenetics, immune, non-coding RNA, oligonucleotides, telomere-associated