中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (5): 1025-1026.doi: 10.4103/1673-5374.355754

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

中枢神经系统的神经炎症和神经胶质激活:代谢观点

  

  • 出版日期:2023-05-15 发布日期:2022-11-01

Neuroinflammation and glial activation in the central nervous system: a metabolic perspective

Assunta Virtuoso#, Ciro De Luca#, Sohaib Ali Korai#, Michele Papa, Giovanni Cirillo*   

  1. Division of Human Anatomy, Laboratory of Morphology of Neuronal Networks and Systems Biology, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy
  • Online:2023-05-15 Published:2022-11-01
  • Contact: Giovanni Cirillo, MD, PhD, giovanni.cirillo@unicampania.it.
  • Supported by:
    This work was supported by grants from Regione Campania (L.R. N.5 Bando 2003 to MP), the Italian Minister of Research and University (PRIN 2007 to MP; PRIN 2017-2017XJ38A4_003 to GC and MP) and UNIMIB (Progetto ID 2019-ATESP-0001 and Progetto ID 2018-CONV-0056 to AV). 

Abstract: Decades of research in glial biology have investigated mechanisms of neuro-glial interplay, demonstrating that neurons and glia intimately cooperate for energy metabolism in the central nervous system (CNS) (Magistretti and Allaman, 2018). As neurons invest their adenosine triphosphate in the neurotransmission, glial cells work to support neurons, providing metabolic substrates. Astrocytes, in particular, contribute largely to energy metabolism in CNS: they sense and shuttle nutrients (e.g., glucose and lipids) and hormones (e.g., insulin), accumulate and utilize glycogen for brain demands, influencing their own metabolism and neuronal activity by lactate transport (astrocyte-neuron lactate shuttle).