中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2615-2618.doi: 10.4103/1673-5374.358604

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

血管化神经移植物的动物模型:系统评价

  

  • 出版日期:2023-12-15 发布日期:2023-06-14

Animal models of vascularized nerve grafts: a systematic review

Francesca Toia*, Daniele Matta, Federico De Michele, Roberto Pirrello, Adriana Cordova   

  1. Plastic and Reconstructive Surgery. Department of Surgical, Oncological and Oral Sciences. University of Palermo, Palermo, Italy
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Francesca Toia, MD, PhD, francesca.toia@unipa.it.

摘要: https://orcid.org/0000-0003-4903-815X (Francesca Toia)

Abstract: The aim of this review is to present and compare the various animal models of vascularized nerve grafts described in the literature as well as to summarize preclinical evidence for superior functional results compared to non-vascularized free nerve grafts. We also will present the state of the art on prefabricated vascularized nerve grafts. A systematic literature review on vascularized nerve graft models was conducted via the retrieval with the PubMed database on March 30, 2019. Data on the animal, nerve, and vascularization model, the recipient bed, the evaluation time points and methods, and the results of the study results were extracted and analyzed from selected articles. The rat sciatic nerve was the most popular model for vascularized nerve grafts, followed by the rabbit; however, rabbit models allow for longer nerve grafts, which are suitable for translational evaluation, and produced more cautious results on the superiority of vascularized nerve grafts. Compared to free nerve grafts, vascularized nerve grafts have better early but similar long-term results, especially in an avascular bed. There are few studies on avascular receiving beds and prefabricated nerve grafts. The clinical translation potential of available animal models is limited, and current experimental knowledge cannot fully support that the differences between vascularized nerve grafts and free nerve grafts yield a clinical advantage that justifies the complexity of the procedure. 

Key words: nerve animal models, nerve grafts, nerve regeneration, peripheral nerves, prefabricated vascularized nerve grafts, vascularized nerve grafts