中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (7): 1493-1494.doi: 10.4103/1673-5374.360278

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

由成年大鼠脂肪组织通过直接细胞转化产生的少突胶质细胞

  

  1. 神经生物学研究服务,拉蒙卡哈尔大学医院,西班牙
  • 出版日期:2023-07-15 发布日期:2023-01-11

Generating oligodendroglia from adult mesenchymal cells for transplantation: cell reprogramming or direct lineage conversion?

Jorge Pascual-Guerra,José A. Rodríguez-Navarro,Carlos L. Paíno* #br#   

  1. Service of Neurobiology-Research, Ramón y Cajal University Hospital – IRYCIS, Madrid, Spain (Pascual-Guerra J, Rodríguez-Navarro JA, Paíno CL)
    Department of Cellular Biology, Complutense University, Madrid, Spain (Rodríguez-Navarro JA)
  • Online:2023-07-15 Published:2023-01-11
  • Contact: Carlos L. Paíno, PhD,carlos.paino@hrc.es
  • Supported by:
    This work was supported by projects NDG09/014 and Proyecto VEXEM (to CLP), European Social Fund, YEI, (Nos. PEJ16/MED/AI-1153 and PEJD-2018-PRE/SAL-8532) of the Community of Madrid, Spain; SAF-2016-78666-R, CP19-0010, and PID 2020-113014RB-I00 funded by MCIN/AEI/10.13039/501100011033 (to JARN).

摘要: https://orcid.org/0000-0001-6667-3310 (Jorge Pascual-Guerra)
https://orcid.org/0000-0002-0741-6338 (José A. Rodríguez-Navarro)
https://orcid.org/0000-0003-4245-592X (Carlos L. Paíno)

Abstract: Cell replacement therapy has long been proposed as a treatment for the damaged nervous system. One of the most challenging aspects of such a strategy, however, is finding sources of donor cells for transplantation. Autologous neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be removed. One possibility would be sourcing precursor or differentiated cells from fetal tissues; however, aside from ethical issues, heterologous cells are at risk of immunological rejection in the long term. Methodological improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.