中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (7): 1397-1403.doi: 10.4103/1673-5374.360345

• 综述:脑损伤修复保护与再生 •    下一篇

旁观者?衰老和脑卒中中的小胶质细胞和淋巴细胞

  


  • 出版日期:2023-07-15 发布日期:2023-01-11

Bystanders or not? Microglia and lymphocytes in aging and stroke

Justin N. Nguyen1, Anjali Chauhan2, *   

  1. 1University of Texas McGovern Medical School at Houston, Houston, TX, USA; 2Department of Neurology, University of Texas McGovern Medical School at Houston, Houston, TX, USA
  • Online:2023-07-15 Published:2023-01-11
  • Contact: Anjali Chauhan, PhD, anjali.chauhan@uth.tmc.edu.
  • Supported by:
    This work was supported by 16POST27490032 American Heart Association post-doctoral fellowship and National Institute of Neurological Disorders and Stroke Exploratory Neuroscience Research Grant R21 NS114836-01A1 (to AC).

摘要: https://orcid.org/0000-0002-9825-8100 (Anjali Chauhan)

Abstract: As the average age of the world population increases, more people will face debilitating aging-associated conditions, including dementia and stroke. Not only does the incidence of these conditions increase with age, but the recovery afterward is often worse in older patients. Researchers and health professionals must unveil and understand the factors behind age-associated diseases to develop a therapy for older patients. Aging causes profound changes in the immune system including the activation of microglia in the brain. Activated microglia promote T lymphocyte transmigration leading to an increase in neuroinflammation, white matter damage, and cognitive impairment in both older humans and rodents. The presence of T and B lymphocytes is observed in the aged brain and correlates with worse stroke outcomes. Preclinical strategies in stroke target either microglia or the lymphocytes or the communications between them to promote functional recovery in aged subjects. In this review, we examine the role of the microglia and T and B lymphocytes in aging and how they contribute to cognitive impairment. Additionally, we provide an important update on the contribution of these cells and their interactions in preclinical aged stroke.

Key words: age, B lymphocytes, brain, central nervous system, cognition, inflammation, microglia, middle cerebral artery occlusion, neuroinflammation, stroke, T lymphocytes, white matter injury