中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (7): 1441-1449.doi: 10.4103/1673-5374.361536

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

糖尿病视网膜病变的表观遗传学修饰和代谢记忆机制

  


  • 出版日期:2023-07-15 发布日期:2023-01-11
  • 基金资助:
    国家自然科学基金(82171062);爱尔眼科医院科研究基金(AF2101D8)

Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface

Dan-Dan Liu1, Chao-Yang Zhang2, 3, Jing-Ting Zhang2, 3, Li-Min Gu4, Guo-Tong Xu1, *, Jing-Fa Zhang2, 3, *   

  1. 1Department of Ophthalmology of Tongji Hospital, Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, China; 2Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University, Shanghai, China; 3National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China; 4Department of Ophthalmology, Shanghai Aier Eye Hospital, Shanghai, China
  • Online:2023-07-15 Published:2023-01-11
  • Contact: Guo-Tong Xu, MD, PhD, gtxu@tongji.edu.cn; Jing-Fa Zhang, MD, PhD, 13917311571@139.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 82171062 (to JFZ) and Aier Eye Hospital Group Scientific Research Fund, No. AF2101D8 (to LMG).

摘要:

表观遗传学主要研究DNA甲基化、组蛋白修饰、染色质重塑以及非编码RNA等DNA序列以外的基因调控机制。在过去的十余年中,研究发现尽管严格控制糖尿病患者的血糖水平,但糖尿病视网膜病变(简称“糖网病”)仍在持续进展。其中,表观遗传修饰和代谢记忆是导致糖网病发展的主要原因之一,但两者的相互关系及潜在作用机制仍尚未阐明。文章总结了来自实验和临床研究的证据,以阐明表观遗传学和代谢记忆在糖网病中的重要性和潜在作用机制,并展示了它们作为生物标志物和治疗靶点的潜能,从而为糖尿病视网膜病变的治疗提出新的见解。

https://orcid.org/0000-0002-0541-7214 (Guo-Tong Xu); https://orcid.org/0000-0003-0601-4342 (Jing-Fa Zhang)

Abstract: Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling, noncoding RNAs, and other gene regulation mechanisms beyond the DNA sequence. In the past decade, epigenetic modifications have drawn more attention as they participate in the development and progression of diabetic retinopathy despite tight control of glucose levels. The underlying mechanisms of epigenetic modifications in diabetic retinopathy still urgently need to be elucidated. The diabetic condition facilitates epigenetic changes and influences target gene expression. In this review, we summarize the involvement of epigenetic modifications and metabolic memory in the development and progression of diabetic retinopathy and propose novel insights into the treatment of diabetic retinopathy. 

Key words: diabetic retinopathy, DNA methylation, epigenetics, histone modification, metabolic memory, M6A modification, non-coding RNAs, review