中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (7): 1478-1485.doi: 10.4103/1673-5374.361537

• 综述:视神经损伤修复保护与再生 • 上一篇    下一篇

干细胞治疗视网膜疾病

  


  • 出版日期:2023-07-15 发布日期:2023-01-11

Stem cell therapy in retinal diseases

Audrey Voisin1, 2, *, Amaury Pénaguin1, 3, Afsaneh Gaillard1, Nicolas Leveziel1, 2   

  1. 1Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM 1084, Poitiers, France; 2Department of Ophthalmology, CHU Poitiers, Poitiers, France; 3Laboratoires Thea, Clermont-Ferrand, France
  • Online:2023-07-15 Published:2023-01-11
  • Contact: Audrey Voisin, PhD, audrey.voisin@univ-poitiers.fr.

摘要: https://orcid.org/0000-0002-9766-5759 (Audrey Voisin)

Abstract: Alteration of the outer retina leads to various diseases such as age-related macular degeneration or retinitis pigmentosa characterized by decreased visual acuity and ultimately blindness. Despite intensive research in the field of retinal disorders, there is currently no curative treatment. Several therapeutic approaches such as cell-based replacement and gene therapies are currently in development. In the context of cell-based therapies, different cell sources such as embryonic stem cells, induced pluripotent stem cells, or multipotent stem cells can be used for transplantation. In the vast majority of human clinical trials, retinal pigment epithelial cells and photoreceptors are the cell types considered for replacement cell therapies. In this review, we summarize the progress made in stem cell therapies ranging from the pre-clinical studies to clinical trials for retinal disease.

Key words: age-related macular degeneration, cell transplantation, clinical trial, retinal disease, retinal dystrophy, stem cell