中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1684-1690.doi: 10.4103/1673-5374.363186

• 综述:脊髓损伤修复保护与再生 • 上一篇    下一篇

嘌呤能受体在脊髓损伤后神经修复和再生中的作用

  

  • 出版日期:2023-08-15 发布日期:2023-02-16
  • 基金资助:
    浙江省自然科学基金(LY19H170003);国家自然科学基金青年基金(81601965)

The role of purinergic receptors in neural repair and regeneration after spinal cord injury

Rui-Dong Cheng1, Wen Ren2, Ben-Yan Luo3, *, Xiang-Ming Ye1, *   

  1. 1Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang Province, China; 2Department of Family Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China; 3Department of Neurology & Brain Medical Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
  • Online:2023-08-15 Published:2023-02-16
  • Contact: Ben-Yan Luo, PhD, MD, luobenyan@zju.edu.cn; Xiang-Ming Ye, MD, yexmdr@hotmail.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81601965 and the Natural Science Foundation of Zhejiang Province, China, No. LY19H170003 (both to RDC).

摘要:

脊髓损伤是一种严重的中枢神经系统损伤,可导致神经功能障碍。脊髓损伤的病理生理机制以及参与神经修复和再生的机制很复杂,目前临床上还未找到有效的干预措施。脊髓损伤后的神经修复和再生是改善伤后神经功能的重要环节,但神经细胞的再生能力低下,脊髓损伤后轴突和髓鞘再生困难,阻碍了功能恢复。脊髓损伤后,大量ATP及其代谢产物被释放出来,通过作用于脊髓中广泛表达的嘌呤受体,介导细胞内和细胞外的信号通路,参与多方面的功能调节,以改善脊髓损伤后的神经修复和再生。文章总结了脊髓损伤中嘌呤能受体的作用机制,突出了嘌呤能受体作为脊髓损伤后神经修复和再生的干预标靶的潜在作用。

https://orcid.org/0000-0002-9892-5778 (Ben-Yan Luo); https://orcid.org/0000-0003-2230-6329 (Xiang-Ming Ye)

Abstract: Spinal cord injury is a serious injury of the central nervous system that results in neurological deficits. The pathophysiological mechanisms underlying spinal cord injury, as well as the mechanisms involved in neural repair and regeneration, are highly complex. Although there have been many studies on these mechanisms, there is no effective intervention for such injury. In spinal cord injury, neural repair and regeneration is an important part of improving neurological function after injury, although the low regenerative ability of nerve cells and the difficulty in axonal and myelin regeneration after spinal cord injury hamper functional recovery. Large amounts of ATP and its metabolites are released after spinal cord injury and participate in various aspects of functional regulation by acting on purinergic receptors which are widely expressed in the spinal cord. These processes mediate intracellular and extracellular signalling pathways to improve neural repair and regeneration after spinal cord injury. This article reviews research on the mechanistic roles of purinergic receptors in spinal cord injury, highlighting the potential role of purinergic receptors as interventional targets for neural repair and regeneration after spinal cord injury.

Key words: glial cells, glial scar, inflammatory responses, neural regeneration, neural repair, neural stem cells, purinergic receptors, spinal cord injury