中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1697-1702.doi: 10.4103/1673-5374.363190

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

产前和产后药物暴露:关注持续的中枢效应

  

  • 出版日期:2023-08-15 发布日期:2023-02-16

Prenatal and postnatal drug exposure: focus on persistent central effects

Giulia Costa1, *, Alexia E. Pollack2   

  1. 1Department of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cagliari, Italy; 2Department of Biology, University of Massachusetts-Boston, Boston, MA, USA
  • Online:2023-08-15 Published:2023-02-16
  • Contact: Giulia Costa, PhD, gcosta@unica.it.
  • Supported by:
    This work was supported by PON AIM (PON RICERCA E INNOVAZIONE 2014-2020, - AZIONE I.2. D.D. N.407 DEL 27 FEBBRAIO 2018 - “ATTRACTION AND INTERNATIONAL MOBILITY”) (to GC) and Fondazione CON IL SUD, The U.S.-Italy Fulbright Commission (to AEP)

摘要: https://orcid.org/0000-0002-0815-9652 (Giulia Costa)

Abstract: Clinical studies indicate significant use of prescription, nonprescription and social/recreational drugs by women during pregnancy; however, limited knowledge exists about the detrimental effects that this practice may have on the developing central nervous system of the fetus. Importantly, few experimental and clinical data are available on how gestational exposure could exacerbate the effects of the same or a different drug consumed by the offspring later in life. The present review summarizes recent findings on the central toxicity elicited by several classes of drugs, administered prenatally and postnatally in experimental animals and humans, focusing on prescription and nonprescription analgesics, anti-inflammatory agents, alcohol and nicotine.

Key words: 3,4-methylenedioxymethamphetamine, acetaminophen, alcohol, chlorpyrifos, dexamethasone, ibuprofen, methadone, neuroinflammation, neurotoxicity, nicotine