中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1719-1720.doi: 10.4103/1673-5374.363196

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

酵母模型中 ER 应激和氧化损伤之间的因果关系

  

  1. 酵母信号网络研究组,i3s - 健康研究与创新研究所,波尔图大学,葡萄牙
  • 出版日期:2023-08-15 发布日期:2023-02-23

Oxidative stress in N88S seipinopathy: novel insights into the mechanisms of neurodegeneration and therapeutic avenues

Vítor Costa, Vitor Teixeira*   

  1. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal (Costa V, Teixeira V)
    Yeast Signalling Networks, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal (Costa V, Teixeira V)
    ICBAS, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal (Costa V) 
  • Online:2023-08-15 Published:2023-02-23
  • Contact: Vitor Teixeira, PhD, vitor.teixeira@ibmc.up.pt.
  • Supported by:
    We thank Dr. Verónica Nogueira, Dr. Che-Kang Chang, Dr. Chung-Yu Lan, and Dr. Clara Pereira for their invaluable contribution for the work herein described. 

Abstract: Lipid droplets (LDs) are ubiquitous cellular organelles that perform functions mostly dedicated to energy homeostasis and lipid metabolism. As neutral lipid depots (triacylglycerol, sterol esters), they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy, a specific form of autophagy devoted to consumption of LDs inside the lysosome. These processes usually reflect adaptation to changes in nutrient availability and membrane buildup during active growth. LDs also contribute to buffering of unsaturated fatty acids, and prevent cellular accumulation of oxidized and peroxidized lipids, thereby providing immediate protection against lipotoxicity and oxidative stress.