中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (8): 1711-1712.doi: 10.4103/1673-5374.363833

• 观点:神经损伤修复保护与再生 • 上一篇    下一篇

增强TGF-β信号以治疗神经系统疾病

  

  • 出版日期:2023-08-15 发布日期:2023-02-16

Augmentation of transforming growth factor-β signaling for the treatment of neurological disorders

Jian Luo*   

  1. Palo Alto Veterans Institute for Research, VA Palo Alto Health Care System, Palo Alto, CA, USA
  • Online:2023-08-15 Published:2023-02-16
  • Contact: Jian Luo, PhD, JLuo@pavir.org.
  • Supported by:
    This work was supported by NIH, Nos. R01NS092868 and RF1AG059694 (both to JL).

摘要: https://orcid.org/0000-0002-2064-8467 (Jian Luo)

Abstract: Members of the transforming growth factor-β (TGF-β) superfamily perform a wide range of essential functions during development and in adulthood, as well as in response to injury and inflammation (Luo, 2022). In the adult central nervous system, TGF-βs and their receptors are widely expressed in all of the major neuronal, glial, and vascular cell types. Members of the TGF-β superfamily are pivotal responders to pathological insults to the brain. Dysfunction of TGF-β signaling contributes to pathogenesis of neurological disorders. Manipulation of TGF-β signaling pathway alters pathological and functional outcomes in models of neurological diseases (Luo, 2022). Therefore, the TGF-β signaling pathway has emerged as a potential therapeutic target against neurological diseases.