中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (11): 2377-2378.doi: 10.4103/1673-5374.371351

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

用缪斯细胞治疗脑卒中

  

  • 出版日期:2023-11-15 发布日期:2023-05-04

Quite amusing stem cells: Muse cells

Molly Monsour, Cesar V. Borlongan*   

  1. University of South Florida Morsani College of Medicine, Tampa, FL, USA (Monsour M) 
    Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL, USA (Borlongan CV) 
  • Online:2023-11-15 Published:2023-05-04
  • Contact: Cesar V. Borlongan, PhD, cborlong@health.usf.edu.
  • Supported by:
    CVB was funded by the National Institutes of Health (NIH) R01NS090962, NIH R01NS102395, and NIH R21NS109575. Additionally, CVB was funded and received royalties and stock options from Astellas, Asterias, Sanbio, Athersys, KMPHC, and International Stem Cell Corporation and has also received consultant compensation from Chiesi Farmaceutici. CVB also declares patents and patent applications related to stem cell therapy.

摘要: https://orcid.org/0000-0002-2966-9782 (Cesar V. Borlongan) 

Abstract: Stem cells may be the future of therapeutics for stroke due to their regenerative and immunomodulatory capabilities. Major barriers faced when employing stem cells, however, include faulty migration, low cell survival, and diminished proliferation. Multilineage-differentiating stress ensuring (Muse) cells, a subset of mesenchymal stem cells, overcome these barriers. Muse cells aid in neuroregeneration, have immense regenerative potential, and are pluripotent, non-tumorigenic, and immunomodulatory. In stroke specifically, these cells may restore an anti-inflammatory environment, regenerate damaged neurons, and integrate into the neuronal architecture. In fact, Muse cells may be aptly designed to ameliorate neurovascular unit damage following stroke and observed in other neuroinflammatory disorders.