中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (11): 2393-2394.doi: 10.4103/1673-5374.371358

• 观点:退行性病与再生 • 上一篇    下一篇

胶质代谢紊乱在神经退行性疾病的病理生理学中的影响

  

  • 出版日期:2023-11-15 发布日期:2023-05-04

Targeting glial metabolism in neurodegenerative diseases: detail matters

Ruqayya Afridi, Kyoungho Suk*   

  1. Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea (Afridi R, Suk K) 
    Department of Biomedical Sciences, BK21 PLUS KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu, South Korea (Afridi R, Suk K) 
    Brain Science and Engineering Institute, Kyungpook National University, Daegu, South Korea (Afridi R, Suk K) 
  • Online:2023-11-15 Published:2023-05-04
  • Contact: Kyoungho Suk, PhD, ksuk@knu.ac.kr.
  • Supported by:
    This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF-2017R1A5A2015391, 2020M3E5D9079764) (to KS).

摘要: https://orcid.org/0000-0002-9555-4203 (Kyoungho Suk)

Abstract: Neurodegenerative diseases, a group of disorders associated with advanced age, are typified by the disease-specific accumulation of mutant proteins and neuroinflammation. For decades, treatment modalities for these disorders have focused on addressing neuronal malfunction, which has resulted in the failure of therapies. Recent studies have identified the crucial role of glial cells in exacerbating neurodegenerative processes via the release of neuroinflammatory mediators. Glia, the major immune component of the central nervous system (CNS), undergo numerous phenotypic transitions and regulate the outcomes of various pathologies (Afridi et al., 2022).