中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2671-2672.doi: 10.4103/1673-5374.373685

• 观点:退行性病与再生 • 上一篇    下一篇

药物化学的历史重现:自然灵感结构作为新型多靶点抗阿尔茨海默病药物的新机遇

  

  • 出版日期:2023-12-15 发布日期:2023-06-14

Historic recurrences in medicinal chemistry: nature-inspired structures as a new opportunity for novel multi-target anti-Alzheimer’s drugs

Luca Piemontese*   

  1. Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia-Scienze del Farmaco, via E. Orabona, Bari, Italy
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Luca Piemontese, PhD, luca.piemontese@uniba.it.

摘要: https://orcid.org/0000-0002-7980-5818 (Luca Piemontese) 

Abstract: Alzheimer’s disease (AD) is an alarming non-communicable, multi-factorial, and non-treatable disease. Its underlying neurodegenerative events have not yet been fully explained and its early diagnosis is very difficult. The appearance of the disease is associated with clinical features such as the degeneration of several cholinergic nuclei of the brain, causing lower levels of the neurotransmitter acetylcholine and the formation of protein aggregates in the inter-synaptic space (amyloid plaques) or inside the cells (neurofibrillary tangles, Brunetti et al., 2020).