中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (12): 2655-2656.doi: 10.4103/1673-5374.373706

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

补体成分8γ链在脑炎症中的意外作用

  

  • 出版日期:2023-12-15 发布日期:2023-06-14

Unexpected role of complement component 8 gamma chain in the inflamed brain

Jong-Heon Kim*, Kyoungho Suk*   

  1. Brain Science and Engineering Institute, Kyungpook National University, Daegu, Republic of Korea (Kim JH, Suk K)
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea (Suk K)
  • Online:2023-12-15 Published:2023-06-14
  • Contact: Jong-Heon Kim, PhD, jongheonkim@knu.ac.kr; Kyoungho Suk, PhD, ksuk@knu.ac.kr.
  • Supported by:
    This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (Nos. NRF-2017R1A5A2015391, 2020M3E5D9079764, to KS).

摘要: https://orcid.org/0000-0001-9349-5804 (Jong-Heon Kim)
https://orcid.org/0000-0002-9555-4203 (Kyoungho Suk)

Abstract: Neuroinflammation, an intricate inflammatory process occurring in the central nervous system (CNS), plays an important role in host defense. Glial cells, including astrocytes and microglia, along with cytokines, chemokines, and the complement system are important components of neuroinflammation. A low level of neuroinflammation is associated with and contributes to various homeostatic and neuroprotective processes, such as removing pathogens or cellular debris and promoting tissue repair after brain injury. However, prolonged or maladaptive neuroinflammation has been implicated in neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis, and major depression. Increasing evidence indicates that targeting neuroinflammation may be a potential therapeutic intervention against neurodegeneration for delaying disease onset or progression. However, our current understanding of neuroinflammation remains limited.