中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (1): 62-68.doi: 10.4103/1673-5374.374139

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

牛磺酸作为神经系统疾病治疗剂

  

  • 出版日期:2024-01-15 发布日期:2023-08-02

Emergence of taurine as a therapeutic agent for neurological disorders

Ashok Jangra1, Priyanka Gola1, Jiten Singh1, Pooja Gond1, Swarnabha Ghosh1, Mahesh Rachamalla2, Abhijit Dey3, Danish Iqbal4, Mehnaz Kamal5, Punya Sachdeva6, Saurabh Kumar Jha7, Shreesh Ojha8, Dinesh Kumar1, *, Niraj Kumar Jha7, 9, 10, *, Hitesh Chopra11, Shing Cheng Tan12, *   

  1. 1Department of Pharmaceutical Sciences, Central University of Haryana, Mahendergarh, Haryana, India; 2Department of Biology, University of Saskatchewan, Saskatoon, SK, Canada; 3Department of Life Sciences, Presidency University, Kolkata, West Bengal, India; 4Department of Health Information Management, College of Applied Medical Sciences, Buraydah Private Colleges, Buraydah, Saudi Arabia; 5Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia; 6GloNeuro, Vishwakarma Road, Noida, India; 7Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh, India; 8Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 9School of Bioengineering & Biosciences, Lovely Professional University, Phagwara, India; 10Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, India; 11Chitkara College of Pharmacy, Chitkara University, Punjab, India; 12UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Online:2024-01-15 Published:2023-08-02
  • Contact: Dinesh Kumar, PhD, dineshbarbola@cuh.ac.in; Niraj Kumar Jha, PhD, niraj.jha@sharda.ac.in; Shing Cheng Tan, PhD, sctan@ukm.edu.my.

摘要: https://orcid.org/0000-0002-5003-399X (Dinesh Kumar); https://orcid.org/0000-0001-9486-4069 (Niraj Kumar Jha); https://orcid.org/0000-0002-0328-0023 (Shing Cheng Tan)

Abstract: Taurine is a sulfur-containing, semi-essential amino acid that occurs naturally in the body. It alternates between inflammation and oxidative stress-mediated injury in various disease models. As part of its limiting functions, taurine also modulates endoplasmic reticulum stress, Ca2+ homeostasis, and neuronal activity at the molecular level. Taurine effectively protects against a number of neurological disorders, including stroke, epilepsy, cerebral ischemia, memory dysfunction, and spinal cord injury. Although various therapies are available, effective management of these disorders remains a global challenge. Approximately 30 million people are affected worldwide. The design of taurine formation could lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders. The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review. This article is a good resource for understanding the general effects of taurine on various diseases. Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms, it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics, with emphasis on mechanism and clinical studies to determine efficacy.

Key words: antioxidant, epilepsy, γ-amino butyric acid, neurodegenerative disorders, neuroprotection, oxidative stress, spinal cord injury, taurine