中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (1): 69-74.doi: 10.4103/1673-5374.374142

• 综述:退行性病与再生 • 上一篇    下一篇

乳酸代谢在神经退行性病中的作用

  

  • 出版日期:2024-01-15 发布日期:2023-08-02

Lactate metabolism in neurodegenerative diseases

Chaoguang Yang1, 2, Rui-Yuan Pan1, Fangxia Guan2, Zengqiang Yuan1, *   

  1. 1The Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China; 2School of Life Sciences, Zhengzhou University, Zhengzhou, Henan Province, China
  • Online:2024-01-15 Published:2023-08-02
  • Contact: Zengqiang Yuan, PhD, zqyuan@bmi.ac.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82230042 and 81930029 (to ZY), U2004201 (to FG and RYP) and the China Postdoctoral Science Foundation, No. 2020M683748 (to RYP).

摘要: https://orcid.org/0000-0001-5739-2867 (Zengqiang Yuan)

Abstract: Lactate, a byproduct of glycolysis, was thought to be a metabolic waste until the discovery of the Warburg effect. Lactate not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological conditions. The Astrocyte-Neuron Lactate Shuttle has clarified that lactate plays a pivotal role in the central nervous system. Moreover, protein lactylation highlights the novel role of lactate in regulating transcription, cellular functions, and disease development. This review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases, thus providing optimal perspectives for future research.

Key words: Alzheimer’s disease, Astrocyte-Neuron Lactate Shuttle, brain, central nervous system, glucose metabolism, glycolysis, neuroinflammation, Parkinson’s disease, protein lactylation, signaling molecule