中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (1): 84-91.doi: 10.4103/1673-5374.375307

• 综述:退行性病与再生 • 上一篇    下一篇

了解多发性硬化症的非运动症状谱:来自动物模型的启示

  

  • 出版日期:2024-01-15 发布日期:2023-08-02

Understanding the spectrum of non-motor symptoms in multiple sclerosis: insights from animal models

Poornima D. E. Weerasinghe-Mudiyanselage1, Joong-Sun Kim1, Taekyun Shin2, Changjong Moon1, *   

  1. 1Department of Veterinary Anatomy and Animal Behavior, College of Veterinary Medicine and BK21 FOUR program, Chonnam National University, Gwangju, Republic of Korea; 2Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Republic of Korea
  • Online:2024-01-15 Published:2023-08-02
  • Contact: Changjong Moon, DVM, MS, PhD, moonc@chonnam.ac.kr.
  • Supported by:
    This work was supported by a grant from the National Research Foundation (NRF) of Korea funded by the Korean Government, No. NRF-2022R1A2C1004022 (to CM).

摘要: https://orcid.org/0000-0003-2451-0374 (Changjong Moon)

Abstract: Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic, physically debilitating neurological disorder. In addition to experiencing motor disability, patients with multiple sclerosis also experience a variety of non-motor symptoms, including cognitive deficits, anxiety, depression, sensory impairments, and pain. However, the pathogenesis and treatment of such non-motor symptoms in multiple sclerosis are still under research. Preclinical studies for multiple sclerosis benefit from the use of disease-appropriate animal models, including experimental autoimmune encephalomyelitis. Prior to understanding the pathophysiology and developing treatments for non-motor symptoms, it is critical to characterize the animal model in terms of its ability to replicate certain non-motor features of multiple sclerosis. As such, no single animal model can mimic the entire spectrum of symptoms. This review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying mechanisms. Further, we highlighted gaps in the literature to explain the non-motor aspects of multiple sclerosis in experimental animal models, which will serve as the basis for future studies.

Key words: anxiety, cognitive deficit, depression, experimental autoimmune encephalomyelitis, motor disability, neurological disorder, pain, pathophysiology, preclinical study, sensory impairments