中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (1): 6-15.doi: 10.4103/1673-5374.375317

• 综述:神经损伤修复保护与再生 •    下一篇

成人神经生成: 一个真实的希望还是一个妄想?

  

  • 出版日期:2024-01-15 发布日期:2023-08-01

Adult neurogenesis: a real hope or a delusion?

Ghulam Hussain1, *, Rabia Akram1, Haseeb Anwar1, Faiqa Sajid1, Tehreem Iman1, Hyung Soo Han2, Chand Raza3, Jose-Luis Gonzalez De Aguilar4#br#   

  1. 1Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, Punjab, Pakistan; 2Department of Physiology, School of Medicine, Clinical Omics Institute, Kyungpook National University, Daegu, Korea; 3Department of Zoology, Faculty of Chemistry and Life Sciences, Government College University, Lahore, Pakistan; 4INSERM, U1118, Mécanismes Centraux et Péripheriques de la Neurodégénérescence, Strasbourg, France, Université de Strasbourg, Strasbourg, France
  • Online:2024-01-15 Published:2023-08-01
  • Contact: Ghulam Hussain, PhD, gh_azer@hotmail.com, or ghulamhussain@gcuf.edu.pk.

摘要: https://orcid.org/0000-0001-9090-7789 (Ghulam Hussain)

Abstract: Adult neurogenesis, the process of creating new neurons, involves the coordinated division, migration, and differentiation of neural stem cells. This process is restricted to neurogenic niches located in two distinct areas of the brain: the subgranular zone of the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle, where new neurons are generated and then migrate to the olfactory bulb. Neurogenesis has been thought to occur only during the embryonic and early postnatal stages and to decline with age due to a continuous depletion of neural stem cells. Interestingly, recent years have seen tremendous progress in our understanding of adult brain neurogenesis, bridging the knowledge gap between embryonic and adult neurogenesis. Here, we discuss the current status of adult brain neurogenesis in light of what we know about neural stem cells. In this notion, we talk about the importance of intracellular signaling molecules in mobilizing endogenous neural stem cell proliferation. Based on the current understanding, we can declare that these molecules play a role in targeting neurogenesis in the mature brain. However, to achieve this goal, we need to avoid the undesired proliferation of neural stem cells by controlling the necessary checkpoints, which can lead to tumorigenesis and prove to be a curse instead of a blessing or hope.

Key words: adult neurogenesis, aging, brain-derived neurotrophic factor, dentate gyrus, hippocampus, neural stem cells, neurotrophic factors, Notch, oxidative stress, stem cells, subgranular zone