中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (1): 154-155.doi: 10.4103/1673-5374.375321

• 观点:视神经损伤修复保护与再生 • 上一篇    下一篇

用于神经炎症疾病模型的高级脑类器官

  

  • 出版日期:2024-01-15 发布日期:2023-08-02

Advanced brain organoids for neuroinflammation disease modeling

Sonia Sabate-Soler#, Henry Kurniawan#, Jens Christian Schwamborn*#br#   

  1. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
  • Online:2024-01-15 Published:2023-08-02
  • Contact: Jens Christian Schwamborn, PhD, jens.schwamborn@uni.lu.

摘要: https://orcid.org/0000-0003-4496-0559 (Jens Christian Schwamborn)

Abstract: Brain organoids mimic closely the embryonic human brain: Over the last decade, the development of human organoid systems has evolved rapidly. Different tissues have been modeled with organoids, such as the gut, lung, liver, kidney retina and brain. These systems have a high cellular heterogeneity, with many cell types integrated into the same system. Organoids’ cellular populations interact between and amongst each other in a cellular and molecular level, which represents an advantage with respects to monolayer 2D cell culture systems.