中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (4): 715-716.doi: 10.4103/1673-5374.382236

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

神经干细胞和祖细胞移植在受损或患病神经系统中的意义

  

  • 出版日期:2024-04-15 发布日期:2023-09-15

Implications of regional identity for neural stem and progenitor cell transplantation in the injured or diseased nervous system

Prakruthi Amar Kumar, Jennifer N. Dulin*#br#   

  1. Department of Biology, Texas A&M University, College Station, TX, USA (Amar Kumar P, Dulin JN) 
    Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX, USA (Dulin JN)
  • Online:2024-04-15 Published:2023-09-15
  • Contact: Jennifer N. Dulin, PhD, jdulin@bio.tamu.edu.
  • Supported by:
    This work was supported by the National Institutes of Health (R01NS116404, to JND); Mission Connect, a program of TIRR Foundation (021-101, to JND).

摘要: https://orcid.org/0000-0001-5767-4290 (Jennifer N. Dulin)

Abstract: Neural stem and progenitor cell (NSPC) transplantation has emerged as a promising therapeutic strategy for replacing lost neuronal populations and repairing damaged neural circuits following nervous system injury and disease. A great deal of experimental work has investigated the biology of NSPC grafting in preclinical animal models; more recently, NSPC transplantation has advanced to clinical trials. However, there are fundamental questions regarding the biology of NSPC grafting that warrant further investigation. Here, we focus on the importance of the regional identity of donor cells for determining outcomes following transplantation. We discuss key findings in models of traumatic brain injury and Parkinson’s disease, focusing on how concepts learned from this work may have potential applications for transplantation following spinal cord injury (SCI).