中国神经再生研究(英文版) ›› 2024, Vol. 19 ›› Issue (4): 721-722.doi: 10.4103/1673-5374.382239

• 观点:退行性病与再生 • 上一篇    下一篇

ATP结合盒转运体作为神经退行性疾病干预的可能靶点的研究进展

  

  • 出版日期:2024-04-15 发布日期:2023-09-15

ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases

Hiu Chuen Lok, Glenda M. Halliday, Woojin Scott Kim*   

  1. Brain and Mind Centre & School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia
  • Online:2024-04-15 Published:2023-09-15
  • Contact: Woojin Scott Kim, PhD, woojin.kim@sydney.edu.au.

摘要: https://orcid.org/0000-0002-4707-933X (Woojin Scott Kim)

Abstract: ATP-binding cassette (ABC) transporters are ubiquitous membrane-bound proteins that are responsible for the translocation of a broad spectrum of substrates across cellular membranes, including lipids, amino acids, nucleosides, sugars, and xenobiotics. Interestingly, ABC transporters are highly expressed in the brain. While their functions in the brain still need to be elucidated, several members are implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal dementia. In this perspective, we will review current knowledge of ABC transporters in the central nervous system in terms of physiological functions and pathology in neurodegeneration. Furthermore, we will explore the possibilities of ABC transporters as potential targets in the development of therapeutics for neurodegenerative diseases.